Wadi Natrun is a depression in Northern Egypt that hosts important evaporitic deposits. Mining of... sodium minerals here started in Pharaonic times, probably as much as about 6000 years ago.
This work investigates the behavior during freeze-drying of packing structures formed by spray-fr...ozen microparticles. A multi-scale approach is used to study spray freeze-drying, and in particular, mass transfer during primary drying and its duration.
The association of an active principle with a nanocarrier is known to improve its stability and p...rotect it from external factors. Nevertheless, loading of nanoparticles with highly hydrophilic substances like caffeine remains a tricky issue.
In the field of pharmaceutical technology, significant attention has been paid on exploiting skin... as a drug administration route. Considering the structural and chemical complexity of the skin barrier, many research works focused on developing an innovative way to enhance skin drug permeation.
A multi-scale approach can be used to simulate the drying behavior of microparticles in packed-be...d.
The freezing step plays a key role in the overall economy of the vacuum freeze-drying of pharmace...uticals, since the nucleation and crystal growth kinetics determine the number and size distribution of the crystals formed.
A computational and modeling approach is used to highlight the key factors that affect polymer na...noparticles (NP) formation in flash nano-precipitation (FNP), when the good solvent, e.g., acetone, is replaced by acetonitrile, tetrahydrofuran and tert-butanol.
Pharmaceutical manufacturing is evolving from traditional batch processes to continuous ones.