English
| Poly(lactide-co-glycolide) (PLGA) is a biodegradable and biocompatible synthetic aliphatic polyester with a well known use in pharmaceutical applications that are under development or already approved by FDA. Florfenicol is a broad-spectrum antibiotic indicated in the treatment of infectious diseases in cattle and pigs. This work is based on the production and characterization of PLGA nanoparticles for the entrapment of florfenicol at different initial concentrations (between 6% and 82% w/w of PLGA) obtained by two different techniques. Confined Impinging Jets Reactors (CIJR) are special devices with a cylindrical chamber where two inlet opposite streams of organic and aqueous phases are discharged and mixed leading to solvent-displacement, also called nanoprecipitation. The hydrophobic PLGA and the drug were dissolved in acetone and mixed into the water phase. The water-miscible solvent immediately diffused leading to polymer precipitation and nanoparticle formation. On the other hand, emulsion-solvent evaporation method was based on the emulsification of PLGA/ethyl acetate phase (containing the drug) into PVA 2%/water phase. Mixing energy was provided by a sonicator. Solvent removal by evaporation resulted in polymer precipitation and nanoparticles formation. |
Publication type:
Conference Proceedings
Evidence for R3C:
N
Publication Date:
Friday, December 10, 2021
Cluster:
Resilient Transition and Sustainable Energy
Year: