In recent years transdermal drug delivery has aroused significant interest as a sustained and non...-invasive way of administering active substances. The development of nanotechnology allowed the development of novel pharmaceutical formulations overcoming skin barrier.
Flash nanoprecipitation (FNP) is a widely used technique to prepare particulate carriers based on... various polymers, and it was proven to be a promising technology for the industrial production of drug loaded nanoparticles.
Drug delivery by means of transdermal patches raised great interest as a non-invasive and sustain...ed therapy. The present research aimed to design a patch for transdermal delivery of melatonin, which was encapsulated in polycaprolactone (PCL) nanoparticles (NPs) by employing flash nanoprecipitation (FNP) technique.
The association of an active principle with a nanocarrier is known to improve its stability and p...rotect it from external factors. Nevertheless, loading of nanoparticles with highly hydrophilic substances like caffeine remains a tricky issue.
In the field of pharmaceutical technology, significant attention has been paid on exploiting skin... as a drug administration route. Considering the structural and chemical complexity of the skin barrier, many research works focused on developing an innovative way to enhance skin drug permeation.