This work investigates the behavior during freeze-drying of packing structures formed by spray-fr...ozen microparticles. A multi-scale approach is used to study spray freeze-drying, and in particular, mass transfer during primary drying and its duration.
The association of an active principle with a nanocarrier is known to improve its stability and p...rotect it from external factors. Nevertheless, loading of nanoparticles with highly hydrophilic substances like caffeine remains a tricky issue.
In the field of pharmaceutical technology, significant attention has been paid on exploiting skin... as a drug administration route. Considering the structural and chemical complexity of the skin barrier, many research works focused on developing an innovative way to enhance skin drug permeation.
A multi-scale approach can be used to simulate the drying behavior of microparticles in packed-be...d.
hapter 6 discusses open- and closed-loop control systems applied to freeze-drying processes, evi...dencing the possibility of model-based approaches for rejection of disturbances, failure prevention, and process optimization.
This chapter introduces readers to the freeze-drying process of pharmaceutical products. Process ...objectives and constraints are presented and discussed, as well as the equipment that carries out the process.
New Metropolitan Perspectives 2018