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On the use of infrared thermography for monitoring a vial freeze-drying process

Monitoring a vial freeze-drying process without interfering with product dynamics is a challengin...g issue. This paper presents a novel device constituted by an IR camera designed to be placed inside the drying chamber, able to monitor the temperature of the vials, very close to that of the product inside.

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An automatic computer vision pipeline for the in-line monitoring of freeze-drying processes

Infrared imaging sensors were proposed in the past years for the real-time monitoring and control... of the Vacuum Freeze Drying (VFD) process. In order to extract reliable, real-time, and quantitative features from images collected by these sensors, a robust and automated image processing pipeline is required.

English

A new mathematical model for monitoring the temporal evolution of the ice crystal size distribution during freezing in pharmaceutical solutions

The freezing step plays a key role in the overall economy of the vacuum freeze-drying of pharmace...uticals, since the nucleation and crystal growth kinetics determine the number and size distribution of the crystals formed.

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