English
| A new Process Analytical Technology (PAT) has been developed and tested for on-line process monit...oring of a vacuum freeze-drying process. The sensor uses an infrared camera to obtain thermal images of the ongoing process and multivariate image analysis (MIA) to extract the information. A reference model was built and different kind of anomalous events were simulated to test the capacity of the system to promptly identify them. Two different data structures and two different algorithms for the imputation of the missing information have been tested and compared. The results show that the MIA-based PAT system is able to efficiently detect on-line undesired events occurring during the vacuum freeze-drying process. |
Publication type:
Journal Articles
Evidence for R3C:
N
Publication Date:
Friday, December 17, 2021
Cluster:
Resilient Transition and Sustainable Energy
Year: