This work is focused on the synthesis of polycaprolactone nanoparticles, coated with chitosan, in... a confined impinging jets reactor using the solvent displacement method. The role of the various reacting species was investigated, evidencing that a biocompatible polymer, e.g.
Drug delivery by means of transdermal patches raised great interest as a non-invasive and sustain...ed therapy. The present research aimed to design a patch for transdermal delivery of melatonin, which was encapsulated in polycaprolactone (PCL) nanoparticles (NPs) by employing flash nanoprecipitation (FNP) technique.
This paper is focused on the production and characterization of polymeric nanoparticles obtained ...by nanoprecipitation. The method consisted of using a confined impinging jet mixer (CIJM), circumventing high-energy equipment.
This manuscript shows how computational models, mainly based on Computational Fluid Dynamics (CFD...), can be used to simulate different parts of an industrial freeze-drying equipment and to properly design them; in particular in this part the duct connecting the chamber with the condenser, with its valves, is considered, while the
The concept of modern closed-loop control was introduced for freeze-dryers in the pharmaceutical ...field in the early Sixties.
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