Davide Fissore

n.a.

Freeze Drying of Pharmaceutical Products provides an overview of the most recent and cutting-edge developments and technologies in the field, focusing on formulation developments and process monitoring and considering new technologies for process development. This book contains case studies from freeze dryer manufacturers and pharmaceutical companies for readers in industry and academia.

The goal of this paper is to review the available process analytical technology tools for monitor...ing the batch freeze-drying process for pharmaceuticals.

This work is focused on the synthesis of polycaprolactone nanoparticles, coated with chitosan, in... a confined impinging jets reactor using the solvent displacement method. The role of the various reacting species was investigated, evidencing that a biocompatible polymer, e.g.

The freezing step plays a key role in the overall economy of the vacuum freeze-drying of pharmace...uticals, since the nucleation and crystal growth kinetics determine the number and size distribution of the crystals formed.

The concept of modern closed-loop control was introduced for freeze-dryers in the pharmaceutical ...field in the early Sixties.

hapter 6 discusses open- and closed-loop control systems applied to freeze-drying processes, evi...dencing the possibility of model-based approaches for rejection of disturbances, failure prevention, and process optimization.