On-line monitoring of the freeze-drying process: A new image-based PAT.
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Monitoring of a vial freeze-drying process with IR thermography.
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On the effect of ultrasound-assisted atmospheric freeze-drying on the antioxidant properties of eggplant
The low operating temperatures employed in atmospheric freeze-drying permits an effective drying ...of heat sensitive products, without any impairment of their quality attributes. When using power ultrasound, the drying rate can be increased, thus reducing the process duration.
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Crystallizing amino acids as bulking agents in freeze-drying
Bulking agents as mannitol (Man) and glycine (Gly) require high bulking agent to stabilizer ratio...s to ensure their crystallization during the freeze-drying process. The aim of this study was to investigate several amino acids (AA) as potential alternative bulking agents in low AA to sucrose (Suc) ratios.
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On the use of infrared thermography for monitoring a vial freeze-drying process
Monitoring a vial freeze-drying process without interfering with product dynamics is a challengin...g issue. This paper presents a novel device constituted by an IR camera designed to be placed inside the drying chamber, able to monitor the temperature of the vials, very close to that of the product inside.
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Monitoring of the freezing stage in a freeze-drying process using IR thermography
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Application of multivariate image analysis for on-line monitoring of a freeze-drying process for pharmaceutical products in vials
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On the use of a micro freeze-dryer for the investigation of the primary drying stage of a freeze-drying process
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An automatic computer vision pipeline for the in-line monitoring of freeze-drying processes
Infrared imaging sensors were proposed in the past years for the real-time monitoring and control... of the Vacuum Freeze Drying (VFD) process. In order to extract reliable, real-time, and quantitative features from images collected by these sensors, a robust and automated image processing pipeline is required.
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Method development and analysis of the water content of the maximally freeze concentrated solution suitable for protein lyophilisation
During freeze-drying of a liquid formulation, a freeze-concentrate is formed in the first phase, ...the freezing step.Understanding the composition of the maximally freeze concentrated solution can help to judge the process stability of biopharmaceuticals during lyophilisation.
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